Corona G, Mannucci E, Schulman C, Petrone L, Mansani R, Cilotti A, Balercia G, Chiarini V, Forti G, Maggi M. Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction. Eur Urol. 2006;50:595,604. doi: 10.1016/j.eururo.2006.02.053. discussion 604. [DOI] [PubMed] [Google Scholar]
Winters SJ, Wang C, Abdelrahaman E, Hadeed V, Dyky MA, Brufsky A. Inhibin-B levels in healthy young adult men and prepubertal boys: Is obesity the cause for the contemporary decline in sperm count because of fewer sertoli cells? J Androl. 2006;27:560β564. doi: 10.2164/jandrol.05193. [DOI] [PubMed] [Google Scholar]
Ghanayem BI, Bai R, Kissling GE, Travlos G, Hoffler U. Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod. 2010;82:96β104. doi: 10.1095/biolreprod.109.078915. [DOI] [PMC free article] [PubMed] [Google Scholar]
Robker RL, Akison LK, Bennett BD, Thrupp PN, Chura LR, Russell DL, Lane M, Norman RJ. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women. J Clin Endocrinol Metab. 2009;94:1533β1540. doi: 10.1210/jc.2008-2648. [DOI] [PubMed] [Google Scholar]
Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod. 1998;13:1502β1505. doi: 10.1093/humrep/13.6.1502. [DOI] [PubMed] [Google Scholar]
Han Z, Mulla S, Beyene J, Liao G, McDonald SD. Maternal underweight and the risk of preterm birth and low birth weight: A systematic review and meta-analyses. Int J Epidemiol. 2011;40:65β101. doi: 10.1093/ije/dyq195. [DOI] [PubMed] [Google Scholar]
Palmer NO, Bakos HW, Owens JA, Setchell BP, Lane M. Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function. Am J Physiol Endocrinol Metab. 2012;302:E768βE780. doi: 10.1152/ajpendo.00401.2011. [DOI] [PubMed] [Google Scholar]
Wise LA, Rothman KJ, Mikkelsen EM, Sorensen HT, Riis AH, Hatch EE. A prospective cohort study of physical activity and time to pregnancy. Fertil Steril. 2012;97:1136,42 e1β1136,42 e4. doi: 10.1016/j.fertnstert.2012.02.025. [DOI] [PMC free article] [PubMed] [Google Scholar]
Gollenberg AL, Liu F, Brazil C, Drobnis EZ, Guzick D, Overstreet JW, Redmon JB, Sparks A, Wang C, Swan SH. Semen quality in fertile men in relation to psychosocial stress. Fertil Steril. 2010;93:1104β1111. doi: 10.1016/j.fertnstert.2008.12.018. [DOI] [PubMed] [Google Scholar]
Volgsten H, Skoog Svanberg A, Ekselius L, Lundkvist O, Sundstrom Poromaa I. Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment. Hum Reprod. 2008;23:2056β2063. doi: 10.1093/humrep/den154. [DOI] [PMC free article] [PubMed] [Google Scholar]
Louis GM, Lum KJ, Sundaram R, Chen Z, Kim S, Lynch CD, Schisterman EF, Pyper C. Stress reduces conception probabilities across the fertile window: Evidence in support of relaxation. Fertil Steril. 2011;95:2184β2189. doi: 10.1016/j.fertnstert.2010.06.078. [DOI] [PMC free article] [PubMed] [Google Scholar]
Calogero A, Polosa R, Perdichizzi A, Guarino F, La Vignera S, Scarfia A, Fratantonio E, Condorelli R, Bonanno O, Barone N. et al. Cigarette smoke extract immobilizes human spermatozoa and induces sperm apoptosis. Reprod Biomed Online. 2009;19:564β571. doi: 10.1016/j.rbmo.2009.05.004. [DOI] [PubMed] [Google Scholar]
Mitra A, Chakraborty B, Mukhopadhay D, Pal M, Mukherjee S, Banerjee S, Chaudhuri K. Effect of smoking on semen quality, FSH, testosterone level, and CAG repeat length in androgen receptor gene of infertile men in an indian city. Syst Biol Reprod Med. 2012;58:255β262. doi: 10.3109/19396368.2012.684195. [DOI] [PubMed] [Google Scholar]
Wegner CC, Clifford AL, Jilbert PM, Henry MA, Gentry WL. Abnormally high body mass index and tobacco use are associated with poor sperm quality as revealed by reduced sperm binding to hyaluronan-coated slides. Fertil Steril. 2010;93:332β334. doi: 10.1016/j.fertnstert.2009.07.970. [DOI] [PubMed] [Google Scholar]
Viloria T, Garrido N, Fernandez JL, Remohi J, Pellicer A, Meseguer M. Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers. Fertil Steril. 2007;88:523β525. doi: 10.1016/j.fertnstert.2006.11.135. [DOI] [PubMed] [Google Scholar]
Saleh RA, Agarwal A, Nada EA, El-Tonsy MH, Sharma RK, Meyer A, Nelson DR, Thomas AJ. Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Fertil Steril. 2003;79(Suppl 3):1597β1605. doi: 10.1016/s0015-0282(03)00337-6. [DOI] [PubMed] [Google Scholar]
Sharara FI, Beatse SN, Leonardi MR, Navot D, SR T Jr. Cigarette smoking accelerates the development of diminished ovarian reserve as evidenced by the clomiphene citrate challenge test. Fertil Steril. 1994;62:257β262. doi: 10.1016/s0015-0282(16)56875-7. [DOI] [PubMed] [Google Scholar]
Olsen J, Bolumar F, Boldsen J, Bisanti L. Does moderate alcohol intake reduce fecundability? A european multicenter study on infertility and subfecundity. european study group on infertility and subfecundity. Alcohol Clin Exp Res. 1997;21:206β212. doi: 10.1111/j.1530-0277.1997.tb03751.x. [DOI] [PubMed] [Google Scholar]
BolΓΊmar F, Olsen J, Rebagliato M, Bisanti L. European Study Group on Infertility and Subfecundity. Caffeine intake and delayed conception: A european multicenter study on infertility and subfecundity. Am J Epidemiol. 1997;145:324β334. doi: 10.1093/oxfordjournals.aje.a009109. [DOI] [PubMed] [Google Scholar]
EliranCnattingius S, Signorello LB, Anneren G, Clausson B, Ekbom A, Ljunger E, Blot WJ, McLaughlin JK, Petersson G, Rane A. et al. Caffeine intake and the risk of first-trimester spontaneous abortion. N Engl J Med. 2000;343:1839β1845. doi: 10.1056/NEJM200012213432503. [DOI] [PubMed] [Google Scholar]
Greenwood DC, Alwan N, Boylan S, Cade JE, Charvill J, Chipps KC, Cooke MS, Dolby VA, Hay AW, Kassam S. et al. Caffeine intake during pregnancy, late miscarriage and stillbirth. Eur J Epidemiol. 2010;25:275β280. doi: 10.1007/s10654-010-9443-7. [DOI] [PubMed] [Google Scholar]
Wisborg K, Kesmodel U, Bech BH, Hedegaard M, Henriksen TB. Maternal consumption of coffee during pregnancy and stillbirth and infant death in first year of life: Prospective study. BMJ. 2003;326:420. doi: 10.1136/bmj.326.7386.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
Selevan SG, Borkovec L, Slott VL, Zudova Z, Rubes J, Evenson DP, Perreault SD. Semen quality and reproductive health of young czech men exposed to seasonal air pollution. Environ Health Perspect. 2000;108:887β894. doi: 10.1289/ehp.00108887. [DOI] [PMC free article] [PubMed] [Google Scholar]
Rubes J, Selevan SG, Evenson DP, Zudova D, Vozdova M, Zudova Z, Robbins WA, Perreault SD. Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality. Hum Reprod. 2005;20:2776β2783. doi: 10.1093/humrep/dei122. [DOI] [PubMed] [Google Scholar]
Ritz B, Wilhelm M, Hoggatt KJ, Ghosh JK. Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the university of california, los angeles. Am J Epidemiol. 2007;166:1045β1052. doi: 10.1093/aje/kwm181. [DOI] [PubMed] [Google Scholar]
Meeker JD, Ehrlich S, Toth TL, Wright DL, Calafat AM, Trisini AT, Ye X, Hauser R. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod Toxicol. 2010;30:532β539. doi: 10.1016/j.reprotox.2010.07.005. [DOI] [PMC free article] [PubMed] [Google Scholar]
Messaros BM, Rossano MG, Liu G, Diamond MP, Friderici K, Nummy-Jernigan K, Daly D, Puscheck E, Paneth N, Wirth JJ. Negative effects of serum p, pβ-DDE on sperm on sperm parameters and modification by genetic polymorphisms. Environ Res. 2009;109:457β464. doi: 10.1016/j.envres.2009.02.009. [DOI] [PubMed] [Google Scholar]
Swan SH, Kruse RL, Liu F, Barr DB, Drobnis EZ, Redmon JB, Wang C, Brazil C, Overstreet JW. The Study for Future Families Research Group. Semen quality in relation to biomarkers of pesticide exposure. Environ Health Perspect. 2003;111:1478β1484. doi: 10.1289/ehp.6417. [DOI] [PMC free article] [PubMed] [Google Scholar]
De Fleurian G, Perrin J, Ecochard R, Dantony E, Lanteaume A, Achard V, Grillo J, Guichaoua M, Botta A, Sari-Minodier I. Occupational exposures obtained by questionnaire in clinical practice and their association with semen quality. J Androl. 2009;30:566β579. doi: 10.2164/jandrol.108.005918. [DOI] [PubMed] [Google Scholar]
Agarwal A, Desai NR, Makker K, Varghese A, Mouradi R, Sabanegh E, Sharma R. Effects of radiofrequency electromagnetic waves (RF-EMW) from cellular phones on human ejaculated semen: An in vitro pilot study. Fertil Steril. 2009;92:1318β1325. doi: 10.1016/j.fertnstert.2008.08.022. [DOI] [PubMed] [Google Scholar]
Falzone N, Huyser C, Becker P, Leszczynski D, Franken DR. The effect of pulsed 900-MHz GSM mobile phone radiation on the acrosome reaction, head morphometry and zona binding of human spermatozoa. Int J Androl. 2011;34:20β26. doi: 10.1111/j.1365-2605.2010.01054.x. [DOI] [PubMed] [Google Scholar]
Mercer CH, Fenton KA, Johnson AM, Wellings K, Macdowall W, McManus S, Nanchahal K, Erens B. Sexual function problems and help seeking behaviour in Britain: National probability sample survey. BMJ. 2003;327:426β427. doi: 10.1136/bmj.327.7412.426. [DOI] [PMC free article] [PubMed] [Google Scholar]
Shefi S, Tarapore PE, Walsh TJ, Croughan M, Turek PJ. Wet heat exposure: a potentially reversible cause of low semen quality in infertile men. Int Braz J Urol. 2007;33:50,6. doi: 10.1590/s1677-55382007000100008. discussion 56β57. [DOI] [PubMed] [Google Scholar]
NCBI home page
Infertility is an increasing problem that affects couples attempting pregnancy. A growing body of evidence points to a link between diet and female fertility. In fact, data show that a diet high in trans fats, refined carbohydrates, and added sugars can negatively affect fertility. Conversely, a diet based on the Mediterranean dietary patterns, i.e., rich in dietary fiber, omega-3 (Ι·-3) fatty acids, plant-based protein, and vitamins and minerals, has a positive impact on female fertility. An unhealthy diet can disrupt microbiota composition, and it is worth investigating whether the composition of the gut microbiota correlates with the frequency of infertility. There is a lack of evidence to exclude gluten from the diet of every woman trying to become pregnant in the absence of celiac disease. Furthermore, there are no data concerning adverse effects of alcohol on female fertility, and caffeine consumption in the recommended amounts also does not seem to affect fertility. On the other hand, phytoestrogens presumably have a positive influence on female fertility. Nevertheless, there are many unanswered questions with regard to supplementation in order to enhance fertility. It has been established that women of childbearing age should supplement folic acid. Moreover, most people experience vitamin D and iodine deficiency; thus, it is vital to control their blood concentrations and consider supplementation if necessary. Therefore, since diet and lifestyle seem to be significant factors influencing fertility, it is valid to expand knowledge in this area.